Brief Summary
We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.
Brief Title
The Longevity Genes in Founder Populations Project
Central Contacts
Central Contact Role
Contact
Central Contact Phone
718-430-3237
Central Contact Email
longevity@aecom.yu.edu
Completion Date
Completion Date Type
Estimated
Conditions
Extreme Longevity
Eligibility Criteria
Inclusion Criteria:
* Ashkenazi Jewish, age 95+,
* Offspring of person age 95+,
* Offspring of parents who died age 70 or younger.
Exclusion Criteria:
* Non-Ashkenazis
* Ashkenazi Jewish, age 95+,
* Offspring of person age 95+,
* Offspring of parents who died age 70 or younger.
Exclusion Criteria:
* Non-Ashkenazis
Inclusion Criteria
Inclusion Criteria:
* Ashkenazi Jewish, age 95+,
* Offspring of person age 95+,
* Offspring of parents who died age 70 or younger.
* Ashkenazi Jewish, age 95+,
* Offspring of person age 95+,
* Offspring of parents who died age 70 or younger.
Gender
All
Gender Based
false
Keywords
95 years of age and older
Healthy Volunteers
No
Last Update Post Date
Last Update Post Date Type
Actual
Last Update Submit Date
Minimum Age
65 Years
NCT Id
NCT00707694
Org Class
Other
Org Full Name
Albert Einstein College of Medicine
Org Study Id
1998-125
Overall Status
Recruiting
Primary Completion Date
Primary Completion Date Type
Estimated
Official Title
Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
Secondary Ids
Secondary Id
2U19AG056278-07A1
Secondary Id
3U19AG056278-06S1
Secondary Id
P01AG021654
Secondary Id
1R56AG088624-01
Secondary Id
R01AG088659
Secondary Id
G42988
Start Date
Start Date Type
Actual
Status Verified Date
First Post Date
First Post Date Type
Estimated
First Submit Date
First Submit QC Date
Study Population
Ashkenazi Jews:
Ages 95 and older, their offspring and control group with no family history of longevity.
Ages 95 and older, their offspring and control group with no family history of longevity.
Std Ages
Older Adult
Maximum Age Number (converted to Years and rounded down)
999
Minimum Age Number (converted to Years and rounded down)
65
Investigators
Investigator Type
Principal Investigator
Investigator Name
Nir Barzilai
Investigator Email
nir.barzilai@einsteinmed.org
Investigator Phone