Brief Summary
This randomized phase II trial studies how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or central nervous system (CNS) primitive neuroectodermal tumors. Drugs used in chemotherapy, such as temozolomide and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether temozolomide and irinotecan hydrochloride are more effective with or without bevacizumab in treating medulloblastoma or CNS primitive neuroectodermal tumors.
Brief Title
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors
Detailed Description
PRIMARY OBJECTIVES:
l. To compare the overall survival (OS) of subjects receiving the combination of temozolomide and irinotecan with that of subjects receiving temozolomide, irinotecan (irinotecan hydrochloride), and bevacizumab for recurrent medulloblastoma (MB)/primitive neuroectodermal tumor (PNET) of childhood.
SECONDARY OBJECTIVES:
I. To assess the response rate for each treatment arm amongst patients who are enrolled with measurable disease.
II. To determine event-free survival (EFS) for each patient compared across regimens.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive temozolomide orally (PO) and irinotecan hydrochloride IV over 90 minutes on days 1-5.
ARM II: Patients receive temozolomide PO and irinotecan hydrochloride IV as in arm I and bevacizumab IV over 30-90 minutes on days 1 and 15.
In both arms, treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 5 years.
l. To compare the overall survival (OS) of subjects receiving the combination of temozolomide and irinotecan with that of subjects receiving temozolomide, irinotecan (irinotecan hydrochloride), and bevacizumab for recurrent medulloblastoma (MB)/primitive neuroectodermal tumor (PNET) of childhood.
SECONDARY OBJECTIVES:
I. To assess the response rate for each treatment arm amongst patients who are enrolled with measurable disease.
II. To determine event-free survival (EFS) for each patient compared across regimens.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive temozolomide orally (PO) and irinotecan hydrochloride IV over 90 minutes on days 1-5.
ARM II: Patients receive temozolomide PO and irinotecan hydrochloride IV as in arm I and bevacizumab IV over 30-90 minutes on days 1 and 15.
In both arms, treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 5 years.
Categories
Completion Date
Completion Date Type
Actual
Conditions
Central Nervous System Neoplasm
Pineoblastoma
Recurrent Medulloblastoma
Recurrent Primitive Neuroectodermal Tumor
Refractory Medulloblastoma
Refractory Peripheral Primitive Neuroectodermal Tumor
Eligibility Criteria
Inclusion Criteria:
* Medulloblastoma or PNET of childhood that has relapsed or become refractory to standard chemotherapy; patients with pineoblastoma are eligible
* Patients must have had histologic verification of the malignancy at original diagnosis or at the time of recurrence
* Patients must have clear residual disease, defined as tumor that is measurable in two perpendicular diameters on magnetic resonance imaging (MRI) OR diffuse leptomeningeal disease OR clear MRI evidence of disease that may not be measurable in two perpendicular diameters
* All patients must have a brain MRI with and without gadolinium and a spine MRI with gadolinium performed within 2 weeks prior to study enrollment
* Patients must have a Lansky or Karnofsky performance status score of \>= 50%, corresponding to Eastern Cooperative Oncology Group (ECOG) categories of 0, 1, or 2 (use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age)
* Patients must have a life expectancy of \>= 8 weeks
* Patients must have experienced at least one and at most two relapses prior to study enrollment; patients with primary refractory disease are eligible
* Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
* Myelosuppressive chemotherapy: Must not have received within 3 weeks of entry onto this study (6 weeks if prior nitrosourea)
* Biologic (anti-neoplastic agent): At least 7 days since the completion of therapy with a biologic agent; at least 3 weeks for biologic agents with a long half life, such as antibodies
* External beam radiation therapy (XRT): Must not have received craniospinal radiotherapy within 24 weeks prior to study entry; the tumor designated as "measurable" for protocol purposes must not have received radiation within 12 weeks prior to study entry); focal radiation to areas of symptomatic metastatic disease must not be given within 14 days of study entry
* Stem cell transplant (SCT): For autologous SCT, \>= 3 months must have elapsed prior to study entry
* Study specific limitations on prior therapy:
* Patients must not have previously received bevacizumab, irinotecan, temozolomide or other anti-vascular endothelial growth factor (VEGF) inhibitor
* Patients must not be taking enzyme-inducing antiepileptic medicines within 1 week of study entry
* Patients must have recovered from any surgical procedure before enrolling on this study:
* Patients with a major surgical procedure within 28 days prior to enrollment should be excluded
* Patients with an intermediate surgical procedure within 14 days prior to enrollment should be excluded
* For minor surgical procedures (including Broviac line or infusaport placement), patients should not receive the first planned dose of bevacizumab until the wound is healed and at least 7 days have elapsed
* There should be no anticipation of need for major surgical procedures during the course of the study
* Examples of major, intermediate, or minor surgical procedures:
* Major procedures: Major craniotomy for tumor resection; organ resection; bowel wall anastomosis; arteriovenous grafts; exploratory laparotomy; thoracotomy
* Intermediate procedures: Ventriculoperitoneal (VP)-shunt placement; stereotactic brain biopsy
* Minor procedures: Incision and drainage of superficial skin abscesses; punch biopsy of skin lesions; superficial skin wound suturing; bone marrow aspirate and/or biopsy; fine needle aspirations; Broviac line or infusaport placement; paracentesis or thoracocentesis
* Please note: Lumbar punctures or placement of peripherally inserted central catheter (PICC) lines are not considered minor procedures and may occur at any time prior to or during therapy
* Hypertension must be well controlled (=\< 95th percentile for age and height if patient is =\< 17 years) on stable doses of medication
* Concomitant medications restrictions:
* Growth factor(s): Must not have received within 7 days of entry onto this study
* Steroids: Patients who are receiving corticosteroids must be on a stable or decreasing dose for at least 7 days
* Study Specific: Patients must not be currently taking nonsteroidal anti-inflammatory drugs (NSAIDs), clopidrogel, dipyridamole or aspirin therapy \> 81 mg/day
* Peripheral absolute neutrophil count (ANC) \>= 1000/uL (must not have received filgrastim \[G-CSF\] within the prior 7 days)
* Platelet count \>= 100,000/uL (transfusion independent)
* Hemoglobin \>= 8.0 gm/dL (may receive packed red blood cell \[PRBC\] transfusions)
* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min OR a serum creatinine based on age/gender as follows:
* =\< 0.4 mg/dL (for patients aged 1 month to \< 6 months)
* =\< 0.5 mg/dL (for patients aged 6 months to \< 1 year)
* =\< 0.6 mg/dL (for patients aged 1 to \< 2 years)
* =\< 0.8 mg/dL (for patients aged 2 to \< 6 years)
* =\< 1 mg/dL (for patients aged 6 to \< 10 years)
* =\< 1.2 mg/dL (for patients aged 10 to \< 13 years)
* =\< 1.4 mg/dL (for female patients aged \>= 13 years)
* =\< 1.5 mg/dL (for male patients aged 13 to \< 16 years)
* =\< 1.7 mg/dL (for male patients aged \>= 16 years)
* Urine protein should be screened by dipstick analysis; if protein \>= 2+ on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio \> 0.5, 24-hour urine protein should be obtained and the level should be \< 1000 mg/24 hours for patient enrollment
* Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age
* Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) =\< 3 x upper limit of normal (ULN) for age
* Central nervous system function defined as
* Patients with a seizure disorder may be enrolled if well-controlled and on non-enzyme inducing anticonvulsants
* Adequate coagulation defined as
* International normalized ratio (INR)/prothrombin time (PT) =\< 1.5 x upper limit of normal
Exclusion Criteria:
* Patients with a serious or non-healing wound, ulcer, or bone fracture are not eligible for this study
* Patients must not have a history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months prior to study entry
* Patients must not have a known bleeding diathesis or coagulopathy
* Patients must not have had significant vascular disease (eg, aortic aneurysm requiring surgical repair, deep venous or arterial thrombosis) within the last 6 months prior to study entry
* Patients must not have a known thrombophilic condition (i.e. protein S, protein C or antithrombin III deficiency, Factor V Leiden, Factor II G20210A mutation, homocysteinemia or antiphospholipid antibody syndrome); testing is not required in patients without thrombophilic history
* Patients must not have evidence of new CNS hemorrhage on baseline MRI obtained within 14 days prior to study enrollment
* Patients with a history of stroke, myocardial infarction, transient ischemic attack (TIA), severe or unstable angina, peripheral vascular disease, or grade II or greater congestive heart failure within the past 6 months are not eligible
* Patients must not have serious and inadequately controlled cardiac arrhythmia
* Female patients who are pregnant are not eligible for this study
* Female patients who are breastfeeding are not eligible for this study unless they agree not to breastfeed
* Female patients of childbearing potential must have a negative pregnancy test
* Sexually active patients of childbearing potential must agree to use an effective method of contraception during the study and for at least 6 months after the completion of bevacizumab therapy
* Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies
* Medulloblastoma or PNET of childhood that has relapsed or become refractory to standard chemotherapy; patients with pineoblastoma are eligible
* Patients must have had histologic verification of the malignancy at original diagnosis or at the time of recurrence
* Patients must have clear residual disease, defined as tumor that is measurable in two perpendicular diameters on magnetic resonance imaging (MRI) OR diffuse leptomeningeal disease OR clear MRI evidence of disease that may not be measurable in two perpendicular diameters
* All patients must have a brain MRI with and without gadolinium and a spine MRI with gadolinium performed within 2 weeks prior to study enrollment
* Patients must have a Lansky or Karnofsky performance status score of \>= 50%, corresponding to Eastern Cooperative Oncology Group (ECOG) categories of 0, 1, or 2 (use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age)
* Patients must have a life expectancy of \>= 8 weeks
* Patients must have experienced at least one and at most two relapses prior to study enrollment; patients with primary refractory disease are eligible
* Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
* Myelosuppressive chemotherapy: Must not have received within 3 weeks of entry onto this study (6 weeks if prior nitrosourea)
* Biologic (anti-neoplastic agent): At least 7 days since the completion of therapy with a biologic agent; at least 3 weeks for biologic agents with a long half life, such as antibodies
* External beam radiation therapy (XRT): Must not have received craniospinal radiotherapy within 24 weeks prior to study entry; the tumor designated as "measurable" for protocol purposes must not have received radiation within 12 weeks prior to study entry); focal radiation to areas of symptomatic metastatic disease must not be given within 14 days of study entry
* Stem cell transplant (SCT): For autologous SCT, \>= 3 months must have elapsed prior to study entry
* Study specific limitations on prior therapy:
* Patients must not have previously received bevacizumab, irinotecan, temozolomide or other anti-vascular endothelial growth factor (VEGF) inhibitor
* Patients must not be taking enzyme-inducing antiepileptic medicines within 1 week of study entry
* Patients must have recovered from any surgical procedure before enrolling on this study:
* Patients with a major surgical procedure within 28 days prior to enrollment should be excluded
* Patients with an intermediate surgical procedure within 14 days prior to enrollment should be excluded
* For minor surgical procedures (including Broviac line or infusaport placement), patients should not receive the first planned dose of bevacizumab until the wound is healed and at least 7 days have elapsed
* There should be no anticipation of need for major surgical procedures during the course of the study
* Examples of major, intermediate, or minor surgical procedures:
* Major procedures: Major craniotomy for tumor resection; organ resection; bowel wall anastomosis; arteriovenous grafts; exploratory laparotomy; thoracotomy
* Intermediate procedures: Ventriculoperitoneal (VP)-shunt placement; stereotactic brain biopsy
* Minor procedures: Incision and drainage of superficial skin abscesses; punch biopsy of skin lesions; superficial skin wound suturing; bone marrow aspirate and/or biopsy; fine needle aspirations; Broviac line or infusaport placement; paracentesis or thoracocentesis
* Please note: Lumbar punctures or placement of peripherally inserted central catheter (PICC) lines are not considered minor procedures and may occur at any time prior to or during therapy
* Hypertension must be well controlled (=\< 95th percentile for age and height if patient is =\< 17 years) on stable doses of medication
* Concomitant medications restrictions:
* Growth factor(s): Must not have received within 7 days of entry onto this study
* Steroids: Patients who are receiving corticosteroids must be on a stable or decreasing dose for at least 7 days
* Study Specific: Patients must not be currently taking nonsteroidal anti-inflammatory drugs (NSAIDs), clopidrogel, dipyridamole or aspirin therapy \> 81 mg/day
* Peripheral absolute neutrophil count (ANC) \>= 1000/uL (must not have received filgrastim \[G-CSF\] within the prior 7 days)
* Platelet count \>= 100,000/uL (transfusion independent)
* Hemoglobin \>= 8.0 gm/dL (may receive packed red blood cell \[PRBC\] transfusions)
* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min OR a serum creatinine based on age/gender as follows:
* =\< 0.4 mg/dL (for patients aged 1 month to \< 6 months)
* =\< 0.5 mg/dL (for patients aged 6 months to \< 1 year)
* =\< 0.6 mg/dL (for patients aged 1 to \< 2 years)
* =\< 0.8 mg/dL (for patients aged 2 to \< 6 years)
* =\< 1 mg/dL (for patients aged 6 to \< 10 years)
* =\< 1.2 mg/dL (for patients aged 10 to \< 13 years)
* =\< 1.4 mg/dL (for female patients aged \>= 13 years)
* =\< 1.5 mg/dL (for male patients aged 13 to \< 16 years)
* =\< 1.7 mg/dL (for male patients aged \>= 16 years)
* Urine protein should be screened by dipstick analysis; if protein \>= 2+ on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio \> 0.5, 24-hour urine protein should be obtained and the level should be \< 1000 mg/24 hours for patient enrollment
* Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age
* Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) =\< 3 x upper limit of normal (ULN) for age
* Central nervous system function defined as
* Patients with a seizure disorder may be enrolled if well-controlled and on non-enzyme inducing anticonvulsants
* Adequate coagulation defined as
* International normalized ratio (INR)/prothrombin time (PT) =\< 1.5 x upper limit of normal
Exclusion Criteria:
* Patients with a serious or non-healing wound, ulcer, or bone fracture are not eligible for this study
* Patients must not have a history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months prior to study entry
* Patients must not have a known bleeding diathesis or coagulopathy
* Patients must not have had significant vascular disease (eg, aortic aneurysm requiring surgical repair, deep venous or arterial thrombosis) within the last 6 months prior to study entry
* Patients must not have a known thrombophilic condition (i.e. protein S, protein C or antithrombin III deficiency, Factor V Leiden, Factor II G20210A mutation, homocysteinemia or antiphospholipid antibody syndrome); testing is not required in patients without thrombophilic history
* Patients must not have evidence of new CNS hemorrhage on baseline MRI obtained within 14 days prior to study enrollment
* Patients with a history of stroke, myocardial infarction, transient ischemic attack (TIA), severe or unstable angina, peripheral vascular disease, or grade II or greater congestive heart failure within the past 6 months are not eligible
* Patients must not have serious and inadequately controlled cardiac arrhythmia
* Female patients who are pregnant are not eligible for this study
* Female patients who are breastfeeding are not eligible for this study unless they agree not to breastfeed
* Female patients of childbearing potential must have a negative pregnancy test
* Sexually active patients of childbearing potential must agree to use an effective method of contraception during the study and for at least 6 months after the completion of bevacizumab therapy
* Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies
Inclusion Criteria
Inclusion Criteria:
* Medulloblastoma or PNET of childhood that has relapsed or become refractory to standard chemotherapy; patients with pineoblastoma are eligible
* Patients must have had histologic verification of the malignancy at original diagnosis or at the time of recurrence
* Patients must have clear residual disease, defined as tumor that is measurable in two perpendicular diameters on magnetic resonance imaging (MRI) OR diffuse leptomeningeal disease OR clear MRI evidence of disease that may not be measurable in two perpendicular diameters
* All patients must have a brain MRI with and without gadolinium and a spine MRI with gadolinium performed within 2 weeks prior to study enrollment
* Patients must have a Lansky or Karnofsky performance status score of \>= 50%, corresponding to Eastern Cooperative Oncology Group (ECOG) categories of 0, 1, or 2 (use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age)
* Patients must have a life expectancy of \>= 8 weeks
* Patients must have experienced at least one and at most two relapses prior to study enrollment; patients with primary refractory disease are eligible
* Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
* Myelosuppressive chemotherapy: Must not have received within 3 weeks of entry onto this study (6 weeks if prior nitrosourea)
* Biologic (anti-neoplastic agent): At least 7 days since the completion of therapy with a biologic agent; at least 3 weeks for biologic agents with a long half life, such as antibodies
* External beam radiation therapy (XRT): Must not have received craniospinal radiotherapy within 24 weeks prior to study entry; the tumor designated as "measurable" for protocol purposes must not have received radiation within 12 weeks prior to study entry); focal radiation to areas of symptomatic metastatic disease must not be given within 14 days of study entry
* Stem cell transplant (SCT): For autologous SCT, \>= 3 months must have elapsed prior to study entry
* Study specific limitations on prior therapy:
* Patients must not have previously received bevacizumab, irinotecan, temozolomide or other anti-vascular endothelial growth factor (VEGF) inhibitor
* Patients must not be taking enzyme-inducing antiepileptic medicines within 1 week of study entry
* Patients must have recovered from any surgical procedure before enrolling on this study:
* Patients with a major surgical procedure within 28 days prior to enrollment should be excluded
* Patients with an intermediate surgical procedure within 14 days prior to enrollment should be excluded
* For minor surgical procedures (including Broviac line or infusaport placement), patients should not receive the first planned dose of bevacizumab until the wound is healed and at least 7 days have elapsed
* There should be no anticipation of need for major surgical procedures during the course of the study
* Examples of major, intermediate, or minor surgical procedures:
* Major procedures: Major craniotomy for tumor resection; organ resection; bowel wall anastomosis; arteriovenous grafts; exploratory laparotomy; thoracotomy
* Intermediate procedures: Ventriculoperitoneal (VP)-shunt placement; stereotactic brain biopsy
* Minor procedures: Incision and drainage of superficial skin abscesses; punch biopsy of skin lesions; superficial skin wound suturing; bone marrow aspirate and/or biopsy; fine needle aspirations; Broviac line or infusaport placement; paracentesis or thoracocentesis
* Please note: Lumbar punctures or placement of peripherally inserted central catheter (PICC) lines are not considered minor procedures and may occur at any time prior to or during therapy
* Hypertension must be well controlled (=\< 95th percentile for age and height if patient is =\< 17 years) on stable doses of medication
* Concomitant medications restrictions:
* Growth factor(s): Must not have received within 7 days of entry onto this study
* Steroids: Patients who are receiving corticosteroids must be on a stable or decreasing dose for at least 7 days
* Study Specific: Patients must not be currently taking nonsteroidal anti-inflammatory drugs (NSAIDs), clopidrogel, dipyridamole or aspirin therapy \> 81 mg/day
* Peripheral absolute neutrophil count (ANC) \>= 1000/uL (must not have received filgrastim \[G-CSF\] within the prior 7 days)
* Platelet count \>= 100,000/uL (transfusion independent)
* Hemoglobin \>= 8.0 gm/dL (may receive packed red blood cell \[PRBC\] transfusions)
* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min OR a serum creatinine based on age/gender as follows:
* =\< 0.4 mg/dL (for patients aged 1 month to \< 6 months)
* =\< 0.5 mg/dL (for patients aged 6 months to \< 1 year)
* =\< 0.6 mg/dL (for patients aged 1 to \< 2 years)
* =\< 0.8 mg/dL (for patients aged 2 to \< 6 years)
* =\< 1 mg/dL (for patients aged 6 to \< 10 years)
* =\< 1.2 mg/dL (for patients aged 10 to \< 13 years)
* =\< 1.4 mg/dL (for female patients aged \>= 13 years)
* =\< 1.5 mg/dL (for male patients aged 13 to \< 16 years)
* =\< 1.7 mg/dL (for male patients aged \>= 16 years)
* Urine protein should be screened by dipstick analysis; if protein \>= 2+ on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio \> 0.5, 24-hour urine protein should be obtained and the level should be \< 1000 mg/24 hours for patient enrollment
* Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age
* Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) =\< 3 x upper limit of normal (ULN) for age
* Central nervous system function defined as
* Patients with a seizure disorder may be enrolled if well-controlled and on non-enzyme inducing anticonvulsants
* Adequate coagulation defined as
* International normalized ratio (INR)/prothrombin time (PT) =\< 1.5 x upper limit of normal
* Medulloblastoma or PNET of childhood that has relapsed or become refractory to standard chemotherapy; patients with pineoblastoma are eligible
* Patients must have had histologic verification of the malignancy at original diagnosis or at the time of recurrence
* Patients must have clear residual disease, defined as tumor that is measurable in two perpendicular diameters on magnetic resonance imaging (MRI) OR diffuse leptomeningeal disease OR clear MRI evidence of disease that may not be measurable in two perpendicular diameters
* All patients must have a brain MRI with and without gadolinium and a spine MRI with gadolinium performed within 2 weeks prior to study enrollment
* Patients must have a Lansky or Karnofsky performance status score of \>= 50%, corresponding to Eastern Cooperative Oncology Group (ECOG) categories of 0, 1, or 2 (use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age)
* Patients must have a life expectancy of \>= 8 weeks
* Patients must have experienced at least one and at most two relapses prior to study enrollment; patients with primary refractory disease are eligible
* Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
* Myelosuppressive chemotherapy: Must not have received within 3 weeks of entry onto this study (6 weeks if prior nitrosourea)
* Biologic (anti-neoplastic agent): At least 7 days since the completion of therapy with a biologic agent; at least 3 weeks for biologic agents with a long half life, such as antibodies
* External beam radiation therapy (XRT): Must not have received craniospinal radiotherapy within 24 weeks prior to study entry; the tumor designated as "measurable" for protocol purposes must not have received radiation within 12 weeks prior to study entry); focal radiation to areas of symptomatic metastatic disease must not be given within 14 days of study entry
* Stem cell transplant (SCT): For autologous SCT, \>= 3 months must have elapsed prior to study entry
* Study specific limitations on prior therapy:
* Patients must not have previously received bevacizumab, irinotecan, temozolomide or other anti-vascular endothelial growth factor (VEGF) inhibitor
* Patients must not be taking enzyme-inducing antiepileptic medicines within 1 week of study entry
* Patients must have recovered from any surgical procedure before enrolling on this study:
* Patients with a major surgical procedure within 28 days prior to enrollment should be excluded
* Patients with an intermediate surgical procedure within 14 days prior to enrollment should be excluded
* For minor surgical procedures (including Broviac line or infusaport placement), patients should not receive the first planned dose of bevacizumab until the wound is healed and at least 7 days have elapsed
* There should be no anticipation of need for major surgical procedures during the course of the study
* Examples of major, intermediate, or minor surgical procedures:
* Major procedures: Major craniotomy for tumor resection; organ resection; bowel wall anastomosis; arteriovenous grafts; exploratory laparotomy; thoracotomy
* Intermediate procedures: Ventriculoperitoneal (VP)-shunt placement; stereotactic brain biopsy
* Minor procedures: Incision and drainage of superficial skin abscesses; punch biopsy of skin lesions; superficial skin wound suturing; bone marrow aspirate and/or biopsy; fine needle aspirations; Broviac line or infusaport placement; paracentesis or thoracocentesis
* Please note: Lumbar punctures or placement of peripherally inserted central catheter (PICC) lines are not considered minor procedures and may occur at any time prior to or during therapy
* Hypertension must be well controlled (=\< 95th percentile for age and height if patient is =\< 17 years) on stable doses of medication
* Concomitant medications restrictions:
* Growth factor(s): Must not have received within 7 days of entry onto this study
* Steroids: Patients who are receiving corticosteroids must be on a stable or decreasing dose for at least 7 days
* Study Specific: Patients must not be currently taking nonsteroidal anti-inflammatory drugs (NSAIDs), clopidrogel, dipyridamole or aspirin therapy \> 81 mg/day
* Peripheral absolute neutrophil count (ANC) \>= 1000/uL (must not have received filgrastim \[G-CSF\] within the prior 7 days)
* Platelet count \>= 100,000/uL (transfusion independent)
* Hemoglobin \>= 8.0 gm/dL (may receive packed red blood cell \[PRBC\] transfusions)
* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min OR a serum creatinine based on age/gender as follows:
* =\< 0.4 mg/dL (for patients aged 1 month to \< 6 months)
* =\< 0.5 mg/dL (for patients aged 6 months to \< 1 year)
* =\< 0.6 mg/dL (for patients aged 1 to \< 2 years)
* =\< 0.8 mg/dL (for patients aged 2 to \< 6 years)
* =\< 1 mg/dL (for patients aged 6 to \< 10 years)
* =\< 1.2 mg/dL (for patients aged 10 to \< 13 years)
* =\< 1.4 mg/dL (for female patients aged \>= 13 years)
* =\< 1.5 mg/dL (for male patients aged 13 to \< 16 years)
* =\< 1.7 mg/dL (for male patients aged \>= 16 years)
* Urine protein should be screened by dipstick analysis; if protein \>= 2+ on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio \> 0.5, 24-hour urine protein should be obtained and the level should be \< 1000 mg/24 hours for patient enrollment
* Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age
* Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) =\< 3 x upper limit of normal (ULN) for age
* Central nervous system function defined as
* Patients with a seizure disorder may be enrolled if well-controlled and on non-enzyme inducing anticonvulsants
* Adequate coagulation defined as
* International normalized ratio (INR)/prothrombin time (PT) =\< 1.5 x upper limit of normal
Gender
All
Gender Based
false
Healthy Volunteers
No
Last Update Post Date
Last Update Post Date Type
Actual
Last Update Submit Date
Maximum Age
21 Years
NCT Id
NCT01217437
Org Class
Nih
Org Full Name
National Cancer Institute (NCI)
Org Study Id
NCI-2011-02605
Overall Status
Completed
Phases
Phase 2
Primary Completion Date
Primary Completion Date Type
Actual
Official Title
Temozolomide With Irinotecan Versus Temozolomide, Irinotecan Plus Bevacizumab (NSC# 704865) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, a COG Randomized Phase II Screening Trial
Primary Outcomes
Outcome Description
Percentage Probability of remaining alive 5 years after enrollment estimated by the method of Kaplan and Meier
Outcome Measure
Overall Survival
Outcome Time Frame
Up to 5 years after enrollment
Secondary Ids
Secondary Id
NCI-2011-02605
Secondary Id
11-00909
Secondary Id
CDR0000686608
Secondary Id
COG-ACNS0821
Secondary Id
ACNS0821
Secondary Id
ACNS0821
Secondary Id
ACNS0821
Secondary Id
U10CA180886
Secondary Id
U10CA098543
Secondary Outcomes
Outcome Description
Patient's best response during protocol therapy coded as complete response, partial response or no response.
Outcome Time Frame
Up to 12 cycles of therapy (11 months)
Outcome Measure
Response
Outcome Description
Percentage Probability of remaining event-free 5 years after enrollment estimated by the method of Kaplan and Meier
Outcome Time Frame
Up to 5 years after enrollment
Outcome Measure
Event-free Survival
Start Date
Start Date Type
Actual
Status Verified Date
First Post Date
First Post Date Type
Estimated
First Submit Date
First Submit QC Date
Std Ages
Child
Adult
Maximum Age Number (converted to Years and rounded down)
21
Minimum Age Number (converted to Years and rounded down)
0
Investigators
Investigator Type
Principal Investigator
Investigator Name
Fatema Malbari
Investigator Email
fmalbari@montefiore.org
Investigator Phone