Improving a Bayesian Model's Survival Estimates in Patients Needing Surgery for Bone Metastases

Brief Summary
The goal of this study is to improve how we estimate survival of people with cancer that has spread to their bone. There have been previous attempts to estimate survival of people with cancer that spread to the bone, but they have not been accurate. This study will try to improve the way we estimate survival in people with cancer that has spread to their bone by looking to see if a physician assessment and a patient assessment of the health status can be blended to give a better estimate of survival than patients or doctors alone.
Brief Title
Improving a Bayesian Model's Survival Estimates in Patients Needing Surgery for Bone Metastases
Completion Date
Completion Date Type
Estimated
Conditions
Bone Metastases
Eligibility Criteria
Inclusion Criteria:

* ≥ to 18 years of age
* Diagnosed with a metastatic malignancy
* histologically proven in oligometastatic disease or by clinical suspicion in widely metastatic disease
* by conventional radiographs, cross sectional imaging and/or scintigraphy
* Scheduled for an orthopaedic operative intervention for skeletal metastases at MSKCC or Montefiore Medical Center including, not limited to the following:
* Resection
* Intramedullary Fixation
* Prophylactic fixation
* Curettage and cementation
* Internal fixation
* Arthroplasty
* Spine stabilization

Exclusion Criteria:

* None
Inclusion Criteria
Inclusion Criteria:

* ≥ to 18 years of age
* Diagnosed with a metastatic malignancy
* histologically proven in oligometastatic disease or by clinical suspicion in widely metastatic disease
* by conventional radiographs, cross sectional imaging and/or scintigraphy
* Scheduled for an orthopaedic operative intervention for skeletal metastases at MSKCC or Montefiore Medical Center including, not limited to the following:
* Resection
* Intramedullary Fixation
* Prophylactic fixation
* Curettage and cementation
* Internal fixation
* Arthroplasty
* Spine stabilization

Gender
All
Gender Based
false
Keywords
questionnaire
11-121
Healthy Volunteers
No
Last Update Submit Date
Minimum Age
18 Years
NCT Id
NCT01470105
Org Class
Other
Org Full Name
Memorial Sloan Kettering Cancer Center
Org Study Id
11-121
Overall Status
Active, not recruiting
Primary Completion Date
Primary Completion Date Type
Estimated
Official Title
Improving a Bayesian Model's Survival Estimates in Patients Needing Surgery for Bone Metastases
Primary Outcomes
Outcome Description
Whether the addition of serum inflammatory cytokines improves the robustness of an existing, validated Bayesian Belief network trained to estimate survival in human patients with operative skeletal metastases.
Outcome Measure
serum inflammatory cytokines
Outcome Time Frame
3 years
Secondary Outcomes
Outcome Description
Whether the addition of chemokine analysis improves the robustness of an existing, validated Bayesian Belief network trained to estimate survival in human patients with operative skeletal metastases.
Outcome Time Frame
3 years
Outcome Measure
chemokine analysis
Outcome Description
Whether the addition of and inclusion of patient-reported SF-36 data, improves the robustness of an existing, validated Bayesian Belief network trained to estimate survival in human patients with operative skeletal metastases.
Outcome Time Frame
3 years
Outcome Measure
patient-reported SF-36 data
Start Date
Status Verified Date
First Submit Date
First Submit QC Date
Study Population
Potential subjects will be recruited by the Orthopaedic Service of the Department of Surgery.
Std Ages
Adult
Older Adult
Maximum Age Number (converted to Years and rounded down)
999
Minimum Age Number (converted to Years and rounded down)
18
Investigators
Investigator Type
Principal Investigator
Investigator Name
Rui Yang
Investigator Email
ryan@montefiore.org
Investigator Phone
ryan