Brief Summary
This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.
Brief Title
Comparison of Standard Versus Low Bicarbonate Hemodialysis
Completion Date
Completion Date Type
Actual
Conditions
Chronic Kidney Disease
Metabolic Acidosis
Eligibility Criteria
Inclusion Criteria:
* Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
* Age \> 18 years
Exclusion Criteria:
* Use of oral alkali within the previous month
* Hospitalization within the previous month
* Inability to provide written informed consent
* Pregnancy
* Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
* Age \> 18 years
Exclusion Criteria:
* Use of oral alkali within the previous month
* Hospitalization within the previous month
* Inability to provide written informed consent
* Pregnancy
Inclusion Criteria
Inclusion Criteria:
* Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
* Age \> 18 years
* Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
* Age \> 18 years
Gender
All
Gender Based
false
Keywords
bicarbonate
dialysis
Healthy Volunteers
No
Last Update Post Date
Last Update Post Date Type
Actual
Last Update Submit Date
Minimum Age
19 Years
NCT Id
NCT01777178
Org Class
Other
Org Full Name
Albert Einstein College of Medicine
Org Study Id
2012-684
Overall Status
Completed
Phases
Phase 1
Primary Completion Date
Primary Completion Date Type
Actual
Official Title
Intradialytic Acid-base Changes and Organic Anion Production With Standard Versus Low Bicarbonate Hemodialysis
Primary Outcomes
Outcome Description
Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Outcome Measure
Change in beta-hydroxybutyrate clearance
Outcome Time Frame
1-2 weeks
Outcome Description
Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Outcome Measure
Change in lactate clearance
Outcome Time Frame
1-2 weeks
Outcome Measure
Post-dialysis pH
Outcome Time Frame
1-2 weeks
Outcome Measure
Post-dialysis bicarbonate
Outcome Time Frame
1-2 weeks
Start Date
Status Verified Date
First Post Date
First Post Date Type
Estimated
First Submit Date
First Submit QC Date
Std Ages
Adult
Older Adult
Maximum Age Number (converted to Years and rounded down)
999
Minimum Age Number (converted to Years and rounded down)
19
Investigators
Investigator Type
Principal Investigator
Investigator Name
Matthew Abramowitz
Investigator Email
matthew.abramowitz@einsteinmed.org
Investigator Phone