Brief Summary
This is an open-label, three-cohort, phase Ib study to determine the safety, recommended phase 2 dose (RP2D), and efficacy of Stereotactic Body Radiation Therapy (SBRT) in combination with either (A) MEDI4736 alone, (B) tremelimumab alone, or (C) the combination of MEDI4736 and tremelimumab for patients with unresectable locally advanced adenocarcinoma of pancreas.
Brief Title
Study of Immune Checkpoint Inhibition With Radiation Therapy in Unresectable, Non-metastatic Pancreatic Cancer
Detailed Description
Patients with unresectable, locally advanced adenocarcinoma of pancreas will receive Stereotactic Body Radiation Therapy (SBRT) at a dose of 6 Gy daily, for 5 days. In Cohort A, where MEDI4736 is given, subjects will receive 10 mg/kg of MEDI4736 every 2 weeks, on the same day as, but after the first dose of SBRT is delivered (within 4 hours). In Cohort B, where tremelimumab is given, subjects will receive 10 mg/kg of tremelimumab every 4 weeks, on the same day as, but after the first dose of SBRT is delivered (within 4 hours). In Cohort C, where MEDI4736 and tremelimumab are given in combination, subjects will receive 10 mg/kg of tremelimumab every 4 weeks, on the same day as, but after the first dose of SBRT is delivered (within 4 hours), followed by 10 mg/kg of MEDI4736 every 4 weeks.
Correlative Studies The investigators will evaluate immune changes in peripheral blood samples and in tumor biopsy fine needle aspirate (FNA) specimens pre- and post- treatment from the 3 cohorts that involve the combination of stereotactic body radiation therapy (SBRT) with either (A) MEDI4736 alone, (B) tremelimumab alone, or (C) the combination of MEDI4736 and tremelimumab. FNA biopsies will be done at baseline (within 30 days of treatment initiation) and Day 28 of cycle 2 (between days 22-28 of cycle 2).
Correlative Studies The investigators will evaluate immune changes in peripheral blood samples and in tumor biopsy fine needle aspirate (FNA) specimens pre- and post- treatment from the 3 cohorts that involve the combination of stereotactic body radiation therapy (SBRT) with either (A) MEDI4736 alone, (B) tremelimumab alone, or (C) the combination of MEDI4736 and tremelimumab. FNA biopsies will be done at baseline (within 30 days of treatment initiation) and Day 28 of cycle 2 (between days 22-28 of cycle 2).
Categories
Completion Date
Completion Date Type
Actual
Conditions
Pancreatic Cancer
Eligibility Criteria
Inclusion:
* Histopathological confirmation of pancreatic adenocarcinoma prior to study entry.
* Unresectable and non-metastatic disease
* At least 1 measurable metastatic lesion by RECIST 1.1, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>20 mm with conventional techniques, or as \>10 mm with spiral computed tomography (CT) scan, and that is accessible for biopsy.
* Age \>18 years
* ECOG performance status 0-1
* Normal organ and marrow function as defined below:
Absolute Neutrophil Count \> 1,000/mcL Platelets ≥ 75,000/mcL Total Bilirubin ≤ 2 x ULN Serum Albumin ≥ 2.5 g/dl ALT or AST up to 3 x ULN if no liver metastases or ALT or AST up to 5 x ULN if liver metastases present Creatinine \< 2 x institution upper limit of normal OR Creatinine Clearance \> 45 mL/min/1.73 m2, as calculated below, for patients with creatinine levels above institutional normal
* No history of another malignancy in the past 5 years, except for treated non-melanoma skin cancer, superficial bladder cancer, or carcinoma-in-situ of the cervix
* No coexisting medical problems that would limit compliance with the study
* Ability to understand and sign a written informed consent document. Patient must have willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures.
* Female subjects of childbearing potential must have a negative serum pregnancy test prior to study entry
* Female subjects of childbearing potential and males must agree to use a highly effective method of contraception for the duration of study treatment, and for six months after discontinuation of the study drug.
Exclusion:
* Resectable, borderline resectable or metastatic disease
* Prior chemotherapy, targeted therapy, immunotherapy, clinical trials or radiotherapy for pancreatic cancer.
* Active or history of concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens, immunosuppressive agents, other investigational therapies, or chronic use of systemic corticosteroids (inhaled and topical steroids are permitted)
* Active or history of chronic autoimmune disease with symptomatic disease within the 3 years before randomization.
* Active or history of inflammatory bowel disease (colitis, Crohn's disease), irritable bowel disease, celiac disease, or other serious, chronic, gastrointestinal conditions associated with diarrhea.
* Diverticulitis within the past 2 years.
* Active HIV infection
* Uncontrolled systemic disease including, but not limited to, ongoing or active systemic infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* Brain metastases
* Patients should not be vaccinated with live attenuated vaccines within 1 month of starting tremelimumab and MEDI4736 treatment.
* History of hypersensitivity reaction to human or mouse antibody products
* Evidence of pre-existing idiopathic pulmonary fibrosis on CT scan at baseline
* Unhealed surgical wound at time of treatment, or history of unhealed surgical wound for more than 30 days
* History of an invasive secondary primary malignancy diagnosed within the previous 3 years, except for appropriately treated stage I endometrial or cervical carcinoma, prostate carcinoma treated surgically or non-melanoma skin cancer.
* Non-protocol antineoplastic agents will not be permitted during this study
* Patients may not recieve other investigational agents.
* Pregnant or lactating women
* Subjects with dementia or significantly altered mental status that would prohibit understanding or rendering of information and consent and compliance with the requirements of the protocol.
* Subjects unable or unwilling to abide by the study protocol or cooperate fully.
* Histopathological confirmation of pancreatic adenocarcinoma prior to study entry.
* Unresectable and non-metastatic disease
* At least 1 measurable metastatic lesion by RECIST 1.1, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>20 mm with conventional techniques, or as \>10 mm with spiral computed tomography (CT) scan, and that is accessible for biopsy.
* Age \>18 years
* ECOG performance status 0-1
* Normal organ and marrow function as defined below:
Absolute Neutrophil Count \> 1,000/mcL Platelets ≥ 75,000/mcL Total Bilirubin ≤ 2 x ULN Serum Albumin ≥ 2.5 g/dl ALT or AST up to 3 x ULN if no liver metastases or ALT or AST up to 5 x ULN if liver metastases present Creatinine \< 2 x institution upper limit of normal OR Creatinine Clearance \> 45 mL/min/1.73 m2, as calculated below, for patients with creatinine levels above institutional normal
* No history of another malignancy in the past 5 years, except for treated non-melanoma skin cancer, superficial bladder cancer, or carcinoma-in-situ of the cervix
* No coexisting medical problems that would limit compliance with the study
* Ability to understand and sign a written informed consent document. Patient must have willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures.
* Female subjects of childbearing potential must have a negative serum pregnancy test prior to study entry
* Female subjects of childbearing potential and males must agree to use a highly effective method of contraception for the duration of study treatment, and for six months after discontinuation of the study drug.
Exclusion:
* Resectable, borderline resectable or metastatic disease
* Prior chemotherapy, targeted therapy, immunotherapy, clinical trials or radiotherapy for pancreatic cancer.
* Active or history of concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens, immunosuppressive agents, other investigational therapies, or chronic use of systemic corticosteroids (inhaled and topical steroids are permitted)
* Active or history of chronic autoimmune disease with symptomatic disease within the 3 years before randomization.
* Active or history of inflammatory bowel disease (colitis, Crohn's disease), irritable bowel disease, celiac disease, or other serious, chronic, gastrointestinal conditions associated with diarrhea.
* Diverticulitis within the past 2 years.
* Active HIV infection
* Uncontrolled systemic disease including, but not limited to, ongoing or active systemic infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* Brain metastases
* Patients should not be vaccinated with live attenuated vaccines within 1 month of starting tremelimumab and MEDI4736 treatment.
* History of hypersensitivity reaction to human or mouse antibody products
* Evidence of pre-existing idiopathic pulmonary fibrosis on CT scan at baseline
* Unhealed surgical wound at time of treatment, or history of unhealed surgical wound for more than 30 days
* History of an invasive secondary primary malignancy diagnosed within the previous 3 years, except for appropriately treated stage I endometrial or cervical carcinoma, prostate carcinoma treated surgically or non-melanoma skin cancer.
* Non-protocol antineoplastic agents will not be permitted during this study
* Patients may not recieve other investigational agents.
* Pregnant or lactating women
* Subjects with dementia or significantly altered mental status that would prohibit understanding or rendering of information and consent and compliance with the requirements of the protocol.
* Subjects unable or unwilling to abide by the study protocol or cooperate fully.
Inclusion Criteria
Inclusion:
* Histopathological confirmation of pancreatic adenocarcinoma prior to study entry.
* Unresectable and non-metastatic disease
* At least 1 measurable metastatic lesion by RECIST 1.1, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>20 mm with conventional techniques, or as \>10 mm with spiral computed tomography (CT) scan, and that is accessible for biopsy.
* Age \>18 years
* ECOG performance status 0-1
* Normal organ and marrow function as defined below:
Absolute Neutrophil Count \> 1,000/mcL Platelets ≥ 75,000/mcL Total Bilirubin ≤ 2 x ULN Serum Albumin ≥ 2.5 g/dl ALT or AST up to 3 x ULN if no liver metastases or ALT or AST up to 5 x ULN if liver metastases present Creatinine \< 2 x institution upper limit of normal OR Creatinine Clearance \> 45 mL/min/1.73 m2, as calculated below, for patients with creatinine levels above institutional normal
* No history of another malignancy in the past 5 years, except for treated non-melanoma skin cancer, superficial bladder cancer, or carcinoma-in-situ of the cervix
* No coexisting medical problems that would limit compliance with the study
* Ability to understand and sign a written informed consent document. Patient must have willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures.
* Female subjects of childbearing potential must have a negative serum pregnancy test prior to study entry
* Female subjects of childbearing potential and males must agree to use a highly effective method of contraception for the duration of study treatment, and for six months after discontinuation of the study drug.
Exclusion:
* Resectable, borderline resectable or metastatic disease
* Prior chemotherapy, targeted therapy, immunotherapy, clinical trials or radiotherapy for pancreatic cancer.
* Active or history of concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens, immunosuppressive agents, other investigational therapies, or chronic use of systemic corticosteroids (inhaled and topical steroids are permitted)
* Active or history of chronic autoimmune disease with symptomatic disease within the 3 years before randomization.
* Active or history of inflammatory bowel disease (colitis, Crohn's disease), irritable bowel disease, celiac disease, or other serious, chronic, gastrointestinal conditions associated with diarrhea.
* Diverticulitis within the past 2 years.
* Active HIV infection
* Uncontrolled systemic disease including, but not limited to, ongoing or active systemic infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* Brain metastases
* Patients should not be vaccinated with live attenuated vaccines within 1 month of starting tremelimumab and MEDI4736 treatment.
* History of hypersensitivity reaction to human or mouse antibody products
* Evidence of pre-existing idiopathic pulmonary fibrosis on CT scan at baseline
* Unhealed surgical wound at time of treatment, or history of unhealed surgical wound for more than 30 days
* History of an invasive secondary primary malignancy diagnosed within the previous 3 years, except for appropriately treated stage I endometrial or cervical carcinoma, prostate carcinoma treated surgically or non-melanoma skin cancer.
* Non-protocol antineoplastic agents will not be permitted during this study
* Patients may not recieve other investigational agents.
* Pregnant or lactating women
* Subjects with dementia or significantly altered mental status that would prohibit understanding or rendering of information and consent and compliance with the requirements of the protocol.
* Subjects unable or unwilling to abide by the study protocol or cooperate fully.
* Histopathological confirmation of pancreatic adenocarcinoma prior to study entry.
* Unresectable and non-metastatic disease
* At least 1 measurable metastatic lesion by RECIST 1.1, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>20 mm with conventional techniques, or as \>10 mm with spiral computed tomography (CT) scan, and that is accessible for biopsy.
* Age \>18 years
* ECOG performance status 0-1
* Normal organ and marrow function as defined below:
Absolute Neutrophil Count \> 1,000/mcL Platelets ≥ 75,000/mcL Total Bilirubin ≤ 2 x ULN Serum Albumin ≥ 2.5 g/dl ALT or AST up to 3 x ULN if no liver metastases or ALT or AST up to 5 x ULN if liver metastases present Creatinine \< 2 x institution upper limit of normal OR Creatinine Clearance \> 45 mL/min/1.73 m2, as calculated below, for patients with creatinine levels above institutional normal
* No history of another malignancy in the past 5 years, except for treated non-melanoma skin cancer, superficial bladder cancer, or carcinoma-in-situ of the cervix
* No coexisting medical problems that would limit compliance with the study
* Ability to understand and sign a written informed consent document. Patient must have willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures.
* Female subjects of childbearing potential must have a negative serum pregnancy test prior to study entry
* Female subjects of childbearing potential and males must agree to use a highly effective method of contraception for the duration of study treatment, and for six months after discontinuation of the study drug.
Exclusion:
* Resectable, borderline resectable or metastatic disease
* Prior chemotherapy, targeted therapy, immunotherapy, clinical trials or radiotherapy for pancreatic cancer.
* Active or history of concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens, immunosuppressive agents, other investigational therapies, or chronic use of systemic corticosteroids (inhaled and topical steroids are permitted)
* Active or history of chronic autoimmune disease with symptomatic disease within the 3 years before randomization.
* Active or history of inflammatory bowel disease (colitis, Crohn's disease), irritable bowel disease, celiac disease, or other serious, chronic, gastrointestinal conditions associated with diarrhea.
* Diverticulitis within the past 2 years.
* Active HIV infection
* Uncontrolled systemic disease including, but not limited to, ongoing or active systemic infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* Brain metastases
* Patients should not be vaccinated with live attenuated vaccines within 1 month of starting tremelimumab and MEDI4736 treatment.
* History of hypersensitivity reaction to human or mouse antibody products
* Evidence of pre-existing idiopathic pulmonary fibrosis on CT scan at baseline
* Unhealed surgical wound at time of treatment, or history of unhealed surgical wound for more than 30 days
* History of an invasive secondary primary malignancy diagnosed within the previous 3 years, except for appropriately treated stage I endometrial or cervical carcinoma, prostate carcinoma treated surgically or non-melanoma skin cancer.
* Non-protocol antineoplastic agents will not be permitted during this study
* Patients may not recieve other investigational agents.
* Pregnant or lactating women
* Subjects with dementia or significantly altered mental status that would prohibit understanding or rendering of information and consent and compliance with the requirements of the protocol.
* Subjects unable or unwilling to abide by the study protocol or cooperate fully.
Gender
All
Gender Based
false
Keywords
Unresectable
Locally Advanced
Non-Metastatic
Healthy Volunteers
No
Last Update Post Date
Last Update Post Date Type
Actual
Last Update Submit Date
Minimum Age
18 Years
NCT Id
NCT02868632
Org Class
Other
Org Full Name
NYU Langone Health
Org Study Id
14-01317
Overall Status
Withdrawn
Phases
Phase 1
Primary Completion Date
Primary Completion Date Type
Actual
Official Title
A Phase I Study of Immune Checkpoint Inhibition (Anti-CTLA4 and/or Anti-PD-L1) in Combination With Radiation Therapy in Patients With Unresectable and Non-metastatic Pancreatic Cancer
Primary Outcomes
Outcome Description
Kaplan Meier curves will be used to summarize Overall Survival.
Outcome Measure
Overall Survival
Outcome Time Frame
24 Months
Secondary Outcomes
Outcome Description
Kaplan Meier curves will be used to summarize Progression-Free Survival.
Outcome Time Frame
24 Months
Outcome Measure
Progression-Free Survival
Outcome Description
Response rates will be estimated with exact 95% confidence intervals for each dose level.
Outcome Time Frame
24 Months
Outcome Measure
Response Evaluation Criteria in Solid Tumors (RECIST 1.1)
Outcome Description
Kaplan Meier curves will be used to summarize Clinical Benefit Rate.
Outcome Time Frame
24 Hours
Outcome Measure
Immune-related Response Criteria (irRC)
Start Date
Start Date Type
Actual
Status Verified Date
First Post Date
First Post Date Type
Estimated
First Submit Date
First Submit QC Date
Std Ages
Adult
Older Adult
Maximum Age Number (converted to Years and rounded down)
999
Minimum Age Number (converted to Years and rounded down)
18
Investigators
Investigator Type
Principal Investigator
Investigator Name
Jennifer Chuy
Investigator Email
jchuy@montefiore.org
Investigator Phone