A Study of Rivoceranib and Trifluridine/Tipiracil for Metastatic Colorectal Cancer (mCRC)

Inclusion Criteria:

1. Histological or cytological confirmation of the diagnosis of mCRC
2. Failure to respond or be intolerant of at least 2 prior regimens of standard anti-cancer treatments (study treatment must be 3rd-line or greater for mCRC). Failed prior treatments may include:

* Fluoropyrimidines-based chemotherapy
* Irinotecan-based chemotherapy
* Oxaliplatin-based chemotherapy
* Anti-Vascular Endothelial Growth Factor (VEGF) biological therapy
* Anti-Epidermal Growth Factor Receptor (EGFR) therapy, if RAS wild-type
* Immunotherapy (for example, nivolumab, pembrolizumab and ipilimumab), in participants with Microsatellite Instability High/Deficient Mismatch Repair (MSI-H/dMMR). Participants who had received adjuvant chemotherapy and had recurrence during or within 6 months of completion of the adjuvant chemotherapy would be considered as 1 prior line of therapy
3. Have progressed based on imaging during or within 3 months of the last administration of most recent therapy
4. Have measurable disease, as defined by RECIST v1.1
5. Adequate bone marrow, renal, and hepatic function, as evidenced by the following within 7 days prior to Cycle 1 Day 1

* Absolute neutrophil count (ANC) ≥1,500/mm3
* Platelets ≥75,000/mm3
* Hemoglobin ≥9.0 g/dL
* Creatinine clearance (according to Cockcroft-Gault Equation or by 24 hr urine collection) \> 50 mL/min and serum creatinine \<1.0× upper limit of normal (ULN)
* Aspartate transaminase (AST) and alanine transaminase (ALT) ≤3.0x ULN (≤5.0 × ULN for participants with liver involvement of their cancer)
* Bilirubin ≤1.5 × ULN
* Alkaline phosphatase ≤2.5 × ULN (≤5 × ULN with liver involvement of their cancer)
* International normalized ratio (INR) / partial thromboplastin time (PTT) ≤1.5 × ULN (Participants currently under treatment with anti-thrombotic agents such as warfarin or heparin with no abnormal coagulation values can participate in this study)
6. Urinary protein \<2+ on dipstick or routine urinalysis. If urine dipstick or routine analysis indicates proteinuria ≥ 2+, a 24-hour urine or urine protein/creatinine ratio must be collected and must demonstrate \<2 g of protein in 24 hours to allow participation in the study.
7. Have an Eastern Cooperative Oncology Group (ECOG) status of 0 or 1

Exclusion Criteria:

1. Prior treatment with rivoceranib or trifluridine/tipiracil
2. Prior treatment with other VEGFR small molecule inhibitors (for example, regorafenib)
3. Packed red blood cell transfusion or erythropoietin therapy within 14 days prior to first dose of study drug
4. History of another malignancy within 3 years prior to Cycle 1 Day 1. A participant with the following malignancies is eligible for this study if, in the opinion of the Investigator, they do not pose a significant risk to life expectancy:

* Carcinoma of the skin without melanomatous features
* Curatively treated cervical carcinoma in situ
* Bladder tumors considered superficial such as noninvasive (T1a) and carcinoma in situ (Tis)
* Thyroid papillary cancer with prior treatment
* Prostate cancer which has been surgically or medically treated and not likely to recur within 3 years

6. Active renal dysfunction that requires dialysis treatments

7. Active cardiac disease including any of the following:

* Congestive heart failure New York Heart Association (NYHA) ≥Class 2
* Myocardial infarction less than 6 months before the start of Cycle 1 Day 1 of treatment

8. Cardiac arrhythmias requiring antiarrhythmic therapy (beta-blockers or digoxin are permitted)

9. History of uncontrolled hypertension (blood pressure ≥140/90 mmHg and/or change in antihypertensive medication within 7 days prior to first dose of study drug)

10. History of antiangiogenic drug class-related severe adverse reactions, including uncontrolled hypertension or others related to prior therapy discontinuation and/or those that may indicate a higher risk to a participant' safety, in the Investigator's opinion, if provided further antiangiogenic treatment.

11. History of vascular disease including arterial or venous embolic events (pulmonary embolism), other than hypertension, within 6 months prior to Cycle 1 Day 1 (for example, hypertensive crisis, hypertensive encephalopathy, stroke or transient ischemic attack \[TIA\], or significant peripheral vascular diseases) that, in the Investigator's opinion, may pose a risk to the participant on VEGF inhibitor therapy.

12. History of clinically significant thrombosis within 3 months prior to first dose of study drug that, in the Investigator's opinion, may place the participant at risk of side effects from antiangiogenics medications

13. History of bleeding diathesis or clinically significant bleeding within 14 days prior to first dose of study drug

14. Therapy with systemic anticoagulant or antithrombotic agents within 7 days prior to first dose of study drug that in the Investigator's opinion could interfere with clotting. The maximum allowable daily dose of aspirin is 325 milligram (mg).

15. Participants with unstable seizure disorder requiring medication changes within 3 months of Cycle 1 Day 1 treatment

16. Untreated or active central nervous system (CNS) or leptomeningeal metastases. Participants are eligible if metastases have been treated and participants are neurologically returned to baseline or neurologically stable (expect for residual signs and symptoms related to the CNS treatment) for at least 4 weeks prior to first dose of study drug. In addition, participants must be either off corticosteroids, or on a stable dose or decreasing dose of ≤ 20 mg daily prednisone or prednisone-equivalent. A baseline radiological assessment of the brain will be performed on participants who have prior history of metastases with CNS involvement

17. History of clinically significant glomerulonephritis, biopsy-proven nephritis, crystal nephropathy or other renal insufficiencies

18. Unresolved adverse reactions \>Grade 1 excluding peripheral neuropathy or treatment related myelosuppression

19. Known hypersensitivity to any of the study drugs, study drug classes, or any components of study drug formulations

20. Inability to swallow oral medications

21. An active malabsorption condition, or any other condition that in the opinion of the Investigator might affect the absorption of study drug