Study To Evaluate D-Ribose For The Treatment of Congestive Heart Failure

Inclusion Criteria:

* written informed consent and Health Insurance Portability and Accountability Act authorization, as applicable;
* symptomatic heart failure (NYHA Class II, III or IV) ≥ 30 days prior to current acute decompensation episode;
* ≥2 of the following signs of acute decompensation: jugular venous distension, rales, dyspnea, and ≥ 1+ pedal edema;
* admitted to the hospital ≤ 36 hours after initial evaluation;
* discontinued from IV inotropic support ≥ 48 hours prior to Screening;
* initiated Screening when subject has met the following criteria for stabilization:
* exacerbating factors addressed;
* near optimal volume status;
* transition from IV to oral diuretic completed;
* near optimal pharmacologic therapy achieved or intolerance documented;
* completed Screening procedures and been randomized to treatment ≤ 7 days after hospital admission;
* LVEF ≤ 35% ≤ 12 months prior to Screening.
* if female, ≥ 2 years post-menopausal, surgically sterile, or practicing effective contraception;
* if female, non-lactating, and if of child-bearing potential, has negative pregnancy test result at Screening;
* willing to abstain from ribose-containing products during study.

Exclusion Criteria:

* significant medical condition(s) which, in Investigator's judgment, could compromise subject's welfare or confound study results;
* significant hepatic, renal, or hematologic disorder/dysfunction beyond that expected from CHF alone;
* Creatinine Clearance \<30.0 mL/min at Screening;
* serum potassium level \<3.5 milliequivalent per liter or \>5.7 milliequivalent per liter, or a serum sodium level \<130 milliequivalent per liter at Screening;
* systolic arterial blood pressure \<90 mm Hg at Screening;
* received ultrafiltration during current admission;
* cardiac surgery ≤ 60 days prior to Screening, except for percutaneous intervention;
* planned revascularization procedures, electrophysiologic device or cardiac mechanical support implantation, cardiac transplantation, or other cardiac surgery ≤ 90 days after study enrollment;
* functional mitral valve regurgitation \> moderate severity;
* aortic regurgitation of at least moderate severity;
* hemodynamically significant primary cardiac valvular disease;
* myocardial infarction ≤ 30 days prior to Screening;
* Acute Coronary Syndrome ≤ 30 days prior to Screening;
* known or suspected right-to-left, bi-directional, or transient right-to-left cardiac shunt;
* sustained ventricular tachycardia or ventricular fibrillation ≤ 30 days prior to Screening, unless automatic implantable cardioverter defibrillator is present;
* atrial fibrillation within the past year;
* CHF related to tachyarrhythmias or bradyarrhythmias;
* CHF due to uncorrected thyroid disease, active myocarditis, or known amyloid cardiomyopathy;
* angina at rest or with slight exertion and/or unstable angina;
* diagnosed with hypertrophic cardiomyopathy;
* cerebrovascular accident ≤ 6 months prior to Screening;
* cardiogenic shock at any time from initial evaluation to randomization;
* on cardiac mechanical support;
* biventricular pacer placement ≤ 60 days prior to Screening or needed pacemaker placement during the current admission;
* refractory, end-stage heart failure;
* type I or type II diabetes;
* history of pancreatitis;
* current systemic infection;
* urinary tract obstruction;
* morbidly obese (weight \> 159 kg \[350 lbs\] or BMI \>42 kg/m2);
* active malignancy at Screening. \[Treatment for basal cell or stage 1 squamous cell carcinoma, or cervical carcinoma in situ allowed\];
* terminally ill or has moribund condition;
* history of irritable bowel syndrome, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, impaction, or similar gastrointestinal conditions;
* currently taking Kayexalate® (sodium polystyrene sulfonate);
* allergic reaction to Optison™ or Definity® or any of their components.